Warm Reactive Autoantibodies: Clinical and Serologic Correlations

Correlation between Warm Reactive Autoantibodies and the Monocyte Monolayer Assay

BACKGROUND: The monocyte monolayer assay (MMA) measures the adherence and phagocytosis of sensitized red cells with peripheral monocytes. The result of MMA may reflect the in vivo destruction of sensitized red blood cells (RBCs). STUDY DESIGN AND METHODS: Blood samples from 20 patients with warm reactive autoantibodies were investigated using the MMA. The Monocyte Index (MI) values > 5% were co...

Correlation Between Warm Reactive Autoantibodies And The Monocyte Monolayer Assay

How do I approach patients with warm-reactive autoantibodies?

W arm-reactive autoantibodies are the most common cause of autoimmune hemolytic anemia, with the incidence of these antibodies increasing with patient age. They have been reported in children as young as a few months of age, and there are two case reports of neonates who seem to have developed warm-reactive autoantibodies in utero. They are a relatively common finding at Arkansas Children’s Hos...

Erythrocyte Membrane Proteins Reactive With IgG (Warm-Reacting) Anti-Red Blood Cell Autoantibodies: 11. Antibodies Coprecipitating

In our initial immunochemical study of the red blood cell (RBCI membrane proteins targeted in 20 cases of warmantibody autoimmune hemolytic anemia (AHA), RBC eluates of 6 patients mediated immunoprecipitation (IP) of both band 3 and glycophorin A (GPA). This dual IP pattern had previously been observed with murine monoclonal antibodies (MoAbs) against the high frequency blood group antigen, Wrb...

Serologic autoantibodies as diagnostic cancer biomarkers--a review.

Current diagnostic techniques used for the early detection of cancers are successful but subject to detection bias. A recent focus lies in the development of more accurate diagnostic tools. An increase in serologic autoantibody levels has been shown to precede the development of cancer disease symptoms. Therefore, autoantibody levels in patient blood serum have been proposed as diagnostic bioma...